Holiday Mathis Horoscope Star Tribune

"Seasonal Affective Disorder (SAD) is a disorder that presents in childhood or teens and is characterized by periods of extreme moodiness, increased eating, and sleep disruption. SAD in younger children or those prone to trauma often results in a manic depression later in life. Many patients do not express symptoms of mania during the early weeks or months of their young adulthood, resulting in misdiagnosis along with delays in initial evaluation." — An Unhealthy Brain Parenchyma: A Hallucinogen Toxicity Linked To Winter Sleep,

"Alterations in circadian timing are highly prevalent in schizophrenia. We hypothesize that the rhythmic cognitive biases observed in schizophrenia overlap with circadian deficits possibly due to a deficit in melatonin signaling; hence, these pathways may be more broadly implicated in disease pathogenesis. Specifically, they may be directly linked to an abnormal nocturnal metabolism induced by schizophrenia-associated environmental stimuli and/or hypoxia. Interestingly, the melatonin rhythm phase shift occurs at night, even under baseline cortisol levels. The phase shift may be caused by a higher nocturnal cortisol level or a decrease in urinary cortisol concentration caused by an increase in both melatonin and cortisol secretions. However, the change in cortisol secretion may affect melatonin production, resulting in evening differences in the nocturnal rhythm. Furthermore, the effect of an additional nocturnal cortisol increase on the nocturnal melatonin rhythm may lead to an aberrant rhythm peak in melatonin secretion. Taken together, these observations may shed new light on the pathophysiology of schizophrenia and suggest a new avenue for treatment targeting circadian rhythms."[i]

"Intrinsic circadian rhythm disorders are developmental disorders that disrupt the generation or maintenance of the circadian rhythm. Impaired sleep time and exaggerated daytime free running have been reported in patients with intrinsically generated circadian rhythm disorders.[i] The predominant mechanism could be deficiency of melatonin biosynthesis and/or production of pineal corticotropin releasing factor (CRF) and/or increased hypothalamic pro-inflammatory cytokines.\cite \href="http://www.ncbi.nlm.nih.